ncRNA name | Dll4 siRNA |
ncRNA Category | siRNA |
Disease name | choroidal neovascularization (CNV) |
Species | Macaca mulatta |
Tissues/Cell_line | rhesus choroid-retinal endothelial cell line RF/6A |
Methods | siRNA transfection, qRT-PCR, Western blot, immunofluorescence staining, MTT assay, tube formation assay |
Expression pattern | associated |
Functional description | Results from the co-culture system showed that the enhancement of Dll4 expression in RF/6A cells led to the significantly faster proliferation and stronger tube forming ability, but inhibited cells migration and invasion across a monolayer of RPE cells in hypoxic environment, while siRNA-mediated Dll4 silencing caused the opposite effects. |
PubMed ID | 21526177 |
Year | 2011 |
Title | Influence of Dll4 via HIF-1α-VEGF signaling on the angiogenesis of choroidal neovascularization under hypoxic conditions. |
Drug-related ncRNA | NO |
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